Helicopters will be used to track down the three-year-old animal, which may be put down as a result of his repeated breakouts from Karoo National Park in the south of the country.
“He is clearly a troublesome lion and could be a danger to humans,” South African National Parks spokesman Reynold Thakhuli told AFP.
“Authorities will have to consider various management methods to ensure his safety and that of people. Such interventions might include euthanizing the animal.”
A signal from Sylvester’s tracking collar, which was fitted after his last escape, showed he was outside the park on Sunday, and by Monday he was 20 kilometres (12 miles) from the park’s fenced boundary, in a mountainous area not easily accessible by foot. He has already killed a cow.