“The two pilots are dead, the nine passengers are injured,” said Bhola Prasad Guragain, a spokesperson for the Tribhuwan International Airport in Kathmandu.
The incident came two days after a Twin Otter turboprop plane crashed into a mountainside in Nepal killing all 23 people on board.
“The plane made a forced landing in Kalikot,” aviation official Pratap Babu Tiwari told AFP, referring to a district in western Nepal.
It was not clear what forced the plane to land and Tiwari said he had no immediate information on casualties.
Nepal Army spokesperson Tara Bahadur Karki said rescue teams had been dispatched to the area.
“We will get more information once the team reaches the site,” Karki said.
The plane was carrying nine passengers and two crew when it took off from an airport in the town of Nepalgunj, 300 kilometres (187 miles) west of Kathmandu.
Air travel is popular in Nepal, which has only a limited road network. Many communities, particularly in the mountains and hills, are accessible only on foot or by air.
The country, which is still reeling from a devastating earthquake last April, has suffered a number of air disasters in recent years, dealing a blow to its tourist industry.