ISLAMABAD: Italian scientists have developed a miniaturized kidney dialysis machine capable of treating the smallest babies, and have for the first time used it to safely treat a newborn baby with multiple organ failure.
This technology has the potential to revolutionize the treatment of infants with acute kidney injury, according to new research published in The Lancet, Science Daily reported.
The new continuous renal replacement therapy (CRRT) machine- named CARPEDIEM (Cardio-Renal Pediatric Dialysis Emergency Machine) was created to overcome the problems of existing dialysis machines that are only designed for adults and have to be adapted for use in newborns and small infants.
“Such modifications make adult devices inaccurate when used in infants smaller than 15kg and can result in complications with fluid management and treatment delivery,” explains lead author Professor Claudio Ronco from San Bortolo Hospital in Vicenza, Italy.
“A major problem is the potential for errors in ultrafiltration volumes — adult dialysis equipment has a tendency to either withdraw too much fluid from a child, leading to dehydration and loss of blood pressure, or too little fluid, leading to high blood pressure and edema.”
To address these technical challenges, Professor Ronco and colleagues developed a miniaturised device for kidney support in newborn babies and small infants weighing between 2kg and 10kg.
It has the capacity to accurately handle very low blood and ultrafiltration flows compared with existing machines, allowing the use of a much smaller sized catheter than is typically used in children, which could prevent damage to blood vessels.
In August, 2013, at the San Bortolo Hospital in Italy, a newborn baby weighing just 2.9kg became the first person in the world to be treated with the device following multiple organ failure due to a complicated delivery.
It is estimated that 18% of low-birthweight infants are affected by acute kidney injury and it is increasingly common in children admitted to hospital, with an incidence of almost 20% in children admitted to intensive care.